Synthesis, Structure Characterization, and Antimicrobial Activity of 2-Amino-3-[(2-Amino-2-Carboxyethyl) Disulfanyl] Propanoic Acid Dihydrogen Triiodide Coordination Compound

Seitzhan Turganbay1,2,Email

Alexandr Ilin1

Nelly Atageldiyeva1

Аrdak Jumagaziyeva1

Sabina Kenesheva1

Gulshat Baigaipova1

Sofia Mun1

1JSC Scientific Center for Anti-Infectious Drugs 050060, Almaty, Republic of Kazakhstan.

2Kazakh-British Technical University, Almaty, Republic of Kazakhstan.

Abstract

The aim of this study was the synthesis of iodine coordination compounds for the treatment of nosocomial infections caused by drug-resistant bacteria. A new 2-amino-3-[(2-amino-2-carboxyethyl) disulfanyl] propanoic acid dihydrogen triiodide coordination compound was synthesized in basic and water media with a stoichiometric ratio of 1:2:2 of Cystine:LiI:iodine. The physico-chemical properties of complex 2-amino-3-[(2-amino-2-carboxyethyl) disulfanyl] propanoic acid dihydrogen triiodide were examined. Obtained crystals were studied by single-crystal X-ray diffraction, FTIR spectroscopy, UV-Vis spectrophotometer and Thermogravimetry/Differential Scanning Colorimeter (TG/DSC). The compound crystallizes in the orthorhombic P212121 with lattice parameters a = 9.5739(19) Å, b = 13.558(3) Å, c = 16.405(3) Å, α = 90, β = 90,

Synthesis, Structure Characterization, and Antimicrobial Activity of 2-Amino-3-[(2-Amino-2-Carboxyethyl) Disulfanyl] Propanoic Acid Dihydrogen Triiodide Coordination Compound