It has been shown by IR spectroscopy that when epoxidized soybean oil (ESO) and swelling polymer are thermostated under conditions close to those of vulcanization, the nature and intensity of the oxirane cycle peak in the range of 900-700 cm-1 (C-O-C) changes in the spectrum. A less noticeable effect with the introduction of Sodium carboxymethyl cellulose (NaCMC) compared with cotton powder (CP) is due to the fact that the most chemically active hydroxyl groups in the C6 position are replaced by carboxyl ones. The TG/DTA method showed the high thermal stability of the swelling filler and the product of its interaction with ESO. It was revealed that upon the introduction of ESO, the composition of rubber compounds filled with powdered cellulose from cotton waste, leads to an increase in tensile strength of the rubbers by 4-7%. Swelling of samples in 10% aqueous solutions of NaCl, KOH, H2SO4 and sodium chloride formation water (pH=6.3) were carried out. It has been established that the swelling capacity of rubbers with ESO is increased by 6-15% compared to samples in which the widely used plasticizer oil PN-6 is introduced.