We report a facile strategy for the fabrication of Tanghulu-like Cu@ZIF-8 nanowires (NWs) by using poly(vinylpyrrolidone)-modified Cu NWs as seeds at normal temperature and pressure. The protecting and directing effects of poly(vinylpyrrolidone) (PVP) are crucial for the in-situ growth of ZIF-8 on Cu NWs. ZIF-8 particles are strung by Cu NW in single Cu@ZIF-8 NW. The catalytic performance of Tanghulu-like Cu@ZIF-8 NWs is much depended on the coverage of ZIF-8 due to the concerted catalysis, resulting in the tuning catalytic performances of beaded and core-shell structures. Particularly, the beaded Cu@ZIF-8 NWs exhibited significantly enhanced catalytic performance for the reduction of 4-nitrophenol (4-NP). ZIF-8 on Cu NWs can offer an enhanced capacity for adsorbing reactants (BH4 - and 4-NP) and rapidly transfer active hydrogen species and 4-NP- toward Cu active sites. This work offers a simple strategy for the architecture of other promising beaded onedimensional structure as enhanced functional materials.