Heat source tower heat pump (HSTHP) system is drawing more and more attention in Yangtze River Region, China, due to its energy-saving characteristics. However, solution dilution occurs when it operates in the heating mode in winter. A high-efficiency solution regeneration of heat source tower based on integration of vacuum boiling and condensation is proposed, and the relative experimental setup is built. The effects of inlet solution concentration, inlet solution temperature, system vacuum value and electric heater outlet valve open time on the performance of its regeneration efficiency and rate are studied. The results show that the regeneration efficiency of the novel system can achieve as high as 4.75 kg kWh-1. Compared with the electric heating regeneration method (1.44 kg kWh-1), this regeneration system shows a great energy saving potential.