Complexation of Antibiotics with Transition Metal Ions: A Review

Naresh Chouhan,1

Milan Hait,2*Email

Gourisankar Roymahapatra,3

Mina Huang,4,5

Ben Bin Xu6

Zhanhu Guo4*Email

1Department of Chemistry, ISBM University, Gariyaband (C.G.)- 493996, India

2Dept. of Chemistry, Dr. C.V. Raman University, Kargi Road, Kota, Bilaspur, C.G.-495113, India.

3School of Applied Sciences and Humanities, Haldia Institute of Technology, Haldia, W.B.- 721657, India

4Advanced Materials Division, Engineered Multifunctional Composites (EMC) Nanotech. LLC, Knoxville, TN 37934 USA

5Integrated Composites Laboratory (ICL), Department of Chemical & Biomolecular Engineering, University of Tennessee, Knoxville, TN 37996, USA

6Mechanical and Construction Engineering, Faculty of Engineering and Environment, Northumbria University, Newcastle upon Tyne NE1 8ST, UK


One of the most significant chemical processes for forming complexes is complexation. Various thermodynamic changes occur during the creation of complexes, which have been examined at various temperatures using various methodologies. The goal of this paper is to provide a general overview of antibiotic-metal ion interactions. How does vary the stability constants and it influences the complex formation. In terms of biological significance, changes in the values of thermodynamic properties like free energy (ΔGo), enthalpy (ΔHo), and entropy (ΔSo­) are far more crucial to the development of complexes. This study is very useful for complexation properties as well as stabilities of antibiotics with metal ions.

Complexation of Antibiotics with Transition Metal Ions: A Review