A Green Chemistry Approach towards Synthesis of Biscoumarins Catalyzed by Different Biocatalysts such as Dragon Fruit Juice, Kiwi Fruit Juice, and Buttermilk Separately by Grind Stone Technique: A Comparative Study

Y. I. Shaikh,1*Email

V. S. Shaikh,1

G. M. Nazeruddin,1

Zamir Shekh,2

G. S. Gugale3 

N. R. Prasad4

1Dept. of Chemistry, Abeda Inamdar Senior College, Pune, Maharashtra, India.

2Dept. of Chemistry, Shri Shivaji College, Akola, Maharashtra, India.

3Haribhai V. Desai College, Pune, Maharashtra, India.

4School of Nano Science and Technology, Shivaji University, Kolhapur, Maharashtra, India 416004

Abstract

We wish to report here with the synthesis of derivatives of bis-coumarin just by grinding 20 mmoles of 4-hydroxy coumarin with ten mmoles of various aromatic aldehydes in the presence of various biocatalysts such as Dragon fruit (Hylocereus undatus, the white-fleshed Pitahaya) Juice/Kiwi fruit (Actinidia deliciosa) Juice and buttermilk as a biocatalyst in the aqueous medium for 10 to 15 minutes at ambient condition. The crude product was obtained by filtration and recrystallized by ethanol. This protocol is a greener approach for organic transformations, thus facilitating the efficient synthesis of bioactive compounds in an environmentally benign way with shorter reaction time, mild reaction conditions, nonhazardous easy workup, and an excellent product yield. This comparative study reveals that rather than fruit juices or buttermilk, the acidic nature of an aqueous medium plays a dominating role in speeding up the reaction. Further, it is also observed that there is not much effect on the yields of the product by using different biocatalysts.

A Green Chemistry Approach towards Synthesis of Biscoumarins Catalyzed by Different Biocatalysts such as Dragon Fruit Juice, Kiwi Fruit Juice, and Buttermilk Separately by Grind Stone Technique: A Comparative Study