Externally Mechanical Force Induced Unusual Defect in the Second Polymorph of Isoniazid/Fumaric Acid Co-crystal
Abstract
In the case of external mechanical forces and other factors, the crystal morphology of the isoniazid/fumaric acid (INH/FUM) co-crystal during the crystallization process will have an impressive phenomenon. Among the two observed polymorphic crystals, namely block shape (Form I) and needle shape (Form II), the second one shows defect by occupying curve morphology. Moreover, the curve crystals show different thermal properties for its original form. This phenomenon suggests the way of defect formation in organic crystal without adding any additives.
