Organic-inorganic hybrid perovskite quantum dots have always been the focus of research in recent years. However, the toxic Pb2+ in MAPbBr3 (MA = CH3NH3+) quantum dots and low stability restrict the application in the field of lighting display. In order to solve this problem, the MA(Pb,Cu) Br3 perovskite quantum dots with replaced Pb2+ with non-toxic Cu2+ were synthesized via the auxiliary ligand precipitation. The phase evolution, controlled-color and fluorescent properties were systematically discussed by the various instruments of XRD, TEM, PL, UV-vis and fluorescence decay analysis. PL spectra monitored at a wavelength of 400 nm excitation shows that the fluorescence emission intensity of quantum dots gradually decreased with the increase of the concentration of Cu2+, and the phenomenon of blue shift appeared. Moreover, the decay lifetime decreased when the dopant concentration of Cu2+ gradually increased. The influence mechanism was studied in detail. In order to improve the stability, the MA(Pb,Cu)Br3@SiO2 quantum dots were prepared by the hydrolysis of TMOS. Meanwhile, the effect of temperature on the fluorescence properties of quantum dots was investigated in detail. The high stability and low toxic of the MA(Pb,Cu)Br3@SiO2 quantum dots will be expected to be used in the field of lighting display and solar cell.