Antimicrobial, Anti-Oxidant and Anti-Tubercular Activity of Coumarin Tethered Thiazole Derivatives

Mamatha S. V1,2,Email

S. L. Belagali2

Mahesh Bhat3

Bhagyashri K Joshi4

1Department of Chemistry, GSI College, Mysore- 570 004, Karnataka, India.
2Environmental Chemistry Laboratory, Department of Studies in Environmental Science, University of Mysore, Manasagangothri, Mysore- 570 006, Karnataka, India.
3Department of Chemistry, Poornaprajna College, Udupi – 576 101, Karnataka, India.
4Department of Biology, GSI College, Mysore- 570 004, Karnataka, India.

Abstract

In the present study two series of coumarin tagged thiazole were synthesized by conjugation of Coumarin thiazolyl amine and benzophenone derivatives. Synthesized title compounds were characterized by the FT-IR, LCMS and NMR spectral techniques. The newly synthesized compounds were screened for the antimicrobial and anti-tubercular (anti-TB) activities. MIC values of the compounds for in-vitro anti-TB activity were 1.6 μg/ml and among all the synthesized compounds, coumarin fused thiazole analog 7f had disclosed potential activity against all the strains of bacteria. Compound 7f interacts through Van der Waal’s interactions into the hydrophobic binding pocket, surrounded by the portions of Ala 698, Phe 699, Gly 772, Cys 773, Leu 694, Val 702, Asn 818, Thr830, Thr 766, Lys 721, Asp 831, Phe 771, Pro 770, Leu 820, Leu 768, Met 769, Ala 719. Biological screening of the synthesized series of compounds reveals that, Compound 7f with electron donating groups was the potent molecule.