An Overview of Yeast-Based Toxicology: Unraveling Molecular Mechanisms, Advancing Drug Discovery, and Addressing Translational Complexities

Ananya Kadekar1

Nithesh Naik2

Antony V Samrot3

Pushpanjali Bhat4,Email

Salmataj S A1,Email

1Department of Biotechnology Manipal Institute of Technology, Manipal Academy of Higher Education, Manipal 576104, Karnataka, India.
2Department of Mechanical and Industrial Engineering Manipal Institute of Technology, Manipal Academy of Higher Education, Manipal 576104, Karnataka, India.
3Faculty of Medicine, MAHSA University, Jenjarom Selangor 42610, Malaysia.
4Department of Chemistry, Manipal Institute of Technology, Manipal Academy of Higher Education, Manipal 576104, Karnataka, India.

Abstract

Saccharomyces cerevisiae, commonly referred to as budding yeast, has become widely recognized as an invaluable model organism for investigating eukaryotic cells. Yeast cells serve as an apt model for studying toxicity due to their convenient genetic manipulability, short life cycle, and easy access to genomic sequences, facilitating straightforward cultivation. Sensitivity to toxic materials is influenced by cellular components. Genes play a role in the transfer, partition, or sequestration of metallic or other toxic substances. These features, along with relevant pathological conditions, have been thoroughly explored and confirmed in the genomic sequence of Saccharomyces cerevisiae. Additionally, this model is effective for investigating the molecular mechanisms that regulate the toxic potential of metals or other harmful substances. Although still in the early stages, these technologies exhibit promise as inventive and effective methods for the development of target-specific therapeutic approaches.

An Overview of Yeast-Based Toxicology: Unraveling Molecular Mechanisms, Advancing Drug Discovery, and Addressing Translational Complexities