Fabrication of pH-electroactive Bacterial Cellulose/Polyaniline Hydrogel for the Development of a Controlled Drug Release System
Sixiang Li, Ashwak Jasim, Weiwei Zhao, Lina Fu, Muhammad Wajid Ullah, Zhijun Shi and Guang Yang
1 Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, PR China
2 School of Mechanical and Electronic Engineering, Wuhan University of Technology, Wuhan 430070, PR China
3 Department of Surgery-Transplant and Mary & Dick Holland Regenerative Medicine Program, University of Nebraska Medical Center, Omaha, NE 68198, USA
Abstract
In the current study, a pH-electroactive hydrogel of bacterial cellulose (BC) and polyaniline (PAni) was fabricated through chemical oxidation polymerization for the development of a controlled drug release system. PAni was densely arrayed along the BC fibers and berberine hydrochloride (BH) was diffused within the hydrogel matrix as confirmed by field emission scanning electron microscope (FESEM) and fourier transform infrared (FTIR) analyses. The pH-electroactive drug release behavior of BC/PAni hydrogel was investigated in vitro. Variation in pH values from 2.2 to 11 demonstrated different drug release profiles from BC/PAni electroactive hydrogel: fast in alkaline and slow in acidic environments as indicated by a color change between green and dark, respectively. The drug release from BC/PAni hydrogel was stable and continuous which showed a typical pH-electroactive drug release behavior. The drug release curves closely matched the Korsemyer-Peppas kinetic model with free diffusion. Owing to its porous nature, conductive properties, and pH-electroactive drug release behavior, the developed BC/PAni hydrogel system can find potential applications as a controlled drug release system.
Publication details
Received: 03 Sep 2018
Revised: 09 Oct 2018
Accepted: 10 Oct 2018
Published online: 11 Oct 2018
Article type:
Research Paper
DOI:
10.30919/esmm5f120
Volume:
1
Page:
41-49
Citation:
ES Materials & Manufacturing, 2018, 1, 41-49
Permissions:
Copyright
Number of downloads:
4038
Citation Information:
43
Description:
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