The time comes now to really think about the national policy over contraceptive pill after COVID-19 mental depression. This planet might face an adverse effect on biodiversity after using such contraceptive pills. After preventing unwanted pregnancy, the consumed birth control pills pass from human to water system and start their undesirable second innings to suppress the fertility in aquatic lives, domestic or wild animals. Besides the aquatic lives, the presence of pill chemicals in urban and suburban water supplies can be boomeranged to innocent people. Thus, a considerable debate is raised in consequence on limit level concern but need to be stopped immediately to stop the infertility problem already, before COVID-19. In detail, steroidal estrogens at pollutant levels can develop breast cancer in women and prostate cancer in men. The steroidal estrogens at pollution level can suppress the growth of root flowering and germination. Ethinyl estradiol (EE2) is a synthetic estrogenic pill, which induces intersex in freshwater fish and caused significant drops in populations. It is the high time to retrospect the national policies on using the estrogenic pill.