Surface Modifications of Superparamagnetic Iron Oxide Nanoparticles with Polylactic Acid-Polyethylene Glycol Diblock Copolymer and Graphene Oxide for a Protein Delivery Vehicle
Linh Doan, Yang Lu, Megha Karatela, Vu Phan, Clayton Jeffryes, Tracy Benson and Evan K. Wujcik
1 Dan F. Smith Department of Chemical Engineering, Lamar University, Beaumont, TX, USA
2 OPERANDO Spectroscopy Laboratory, Dan F. Smith Department of Chemical Engineering, Lamar University, Beaumont, TX, USA
3 Materials Engineering And Nanosensor (MEAN) Laboratory, Department of Chemical and Biological Engineering, The University of Alabama, Tuscaloosa, AL, USA
4 Nanobiomaterials and Bioprocessing (NAB) Laboratory, Dan F. Smith Department of Chemical Engineering, Lamar University, Beaumont, TX, USA
Abstract
As a protein delivery vehicle, superparamagnetic iron oxide nanoparticles (SPION) with an average size of 19.6 ± 4.8 nm were coated with polylactic acid (PLA) (5000)-polyethylene glycol (PEG) (10000) diblock copolymer and single layer graphene oxide (GO). Bovine serum albumin was selected as the model protein, and the drug loading capacity of the designed vehicle is 2013 ± 79 mg g-1. The drug release result shows that the average percentage of cumulative drug release after 47 days in vitro is 37.7% ± 1.4%.
Publication details
Article type:
Research Paper
Published online:
24 Apr 2019
DOI:
10.30919/es8d510
Volume:
7
Page:
10-16
Citation:
Engineered Science, 2019, 7, 10-16
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Description:
The presented protein delivery vehicle of PLA-PEG/GO outperfoms other vehicles in protein enrapment ....
The presented protein delivery vehicle of PLA-PEG/GO outperfoms other vehicles in protein enrapment efficiency and cumulative drug release percentage.
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